Cannabinoids Can Kill Gastric Cancers Cells

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A new study published in the journal Chemotherapy has found that cannabinoid receptor activation – something done naturally by cannabis and cannabinoids – can lead to the death of gastric cancer cells.
For the study, researchers at the Catholic University of Korea’s Department of Internal Medicine studied the effects of a cannabinoid receptor agonist (which cannabis is) on mice injected with gastric cancer cells.
It was found that, after 14 days, “Tumor volume decreased by 30% in the WIN 55,212-2 [a cannabinoid receptor agonist] -treated group.. Apoptotic [self-destructed] cells were found more commonly in the WIN 55,212-2 treatment group than in the control on immunohistochemistry.”
Researchers conclude that activation of cannabinoid receptors has “antineoplastic effect [the ability to kill cancer cells] on the gastric cancers in in vivo model.”
The full study can be found on the website for the U.S. Library of Medicine by clicking here.

Cannabis Kills Brain Cancer Cells, According to Study

marijuana-leaf
A study published in the Journal of Clinical Investigation found that THC (delta-9-tetrahydrocannabinol) – a prime component of cannabis – can kill brain cancer cells by causing them to self-digest.
Researchers for the study examined mice subjects which were implanted with human cancer cells, as well as several human subjects with brain tumors, and found that THC causes brain cancer cells to undergo a process called autophagy; according to WebMD, autophagy is the “breakdown of a cell that occurs when the cell essentially self-digests.”
“These results may help to design new cancer therapies based on the use of medicines containing the active principle of marijuana and/or in the activation of autophagy,” says Guillermo Velasco, co-author of the study.
Researchers found no negative effect associated with the THC administered to the subjects of the study, which was published originally in 2009 and was conducted by researchers at Complutense University in Spain

Cannabinoids Destroy Cancer Cells, Prevents Them From Growing

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A new study published online by the journal Anticancer Research has found that cannabinoids can “destroy” cancer cells, and prevent them from growing.
For the study, researchers tested six different cannabis-based cannabinoids (such as cannabidiol and cannabigerol) in their relation to leukemia cells. It was found that each of these cannabinoids were shown to be effective at combating the leukemia cells.
“Of six cannabinoids studied, each demonstrated anti-cancer properties as effective as those seen in THC. Importantly, they had an increased effect on cancer cells when combined with each other”, according to a press release for the study, sent out today.
“This study is a critical step in unpicking the mysteries of cannabis as a source of medicine. The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising”, says Dr. Wai Liu, lead author of the study.
She continues; “These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own.”
“Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer. Significantly, these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future.”

Top Ten Marijuana Studies From 2013

marijuana science
2013 has been an incredible year for cannabis-related science, with dozens of peer-reviewed studies being released examining the benefits of cannabis ranging from weight-loss, to cancer-killing capabilities. Here we breakdown the ten most important (and groundbreaking) studies released this year.
1. THC May Treat Inflammatory Diseases and Cancer By Altering Genes
A government funded study published by the Journal of Biological Chemistry found that THC may actually alter certain genes in our body, which can result in a positive effect on a number of conditions, especially cancers and inflammatory diseases. This is the first study of its kind to find such a direct link between cannabinoids, and the alteration of genes.
2. Cannabis Combats Brain Degeneration and Increases Stamina
A study conducted at the Institute of Molecular Psychiatry at the University of Bonn in Germany found that cannabis triggers the release of antioxidants, which acts as a cleansing mechanism, resulting in the removal of damaged cells and improving the efficiency of mitochondria, the energy source that powers cells, potentially increasing stamina.
“These discoveries shed new insight on how natural marijuana cannabinoids hold the capacity to literally kill the brain inflammation responsible for causing cognitive decline, neural failure, and brain degeneration”, says Gery Wenk, a professor of neuroscience, immunology and medical genetics at Ohio State University.
3. Cannabis Can Stop Seizures
A study published by the British Journal of Pharmacology found that cannabis can stop seizures due to its “significant anticonvulsant effects”.
4. THC Provides Protection from Heart Attacks
Research published this year in the journal Biochemical Pharmacology found that even minuscule amounts of THC can provide protection from heart attacks, as well as reduce the potential cardiovascular damage associated with suffering one.
For the study researchers administered extremely small amounts of THC; 0.002 mg/kg, which is up to 10,000 times less potent than the average joint. Despite how small the dose was, researchers found it to be effective at protecting against heart attacks when administered 2 to 48 hours before an attack, and found it to help relieve the symptoms when administered afterward.
“[THC] is a safe and effective treatment that reduces myocardial ischemic (heart attack) damage”, states the study. It concludes: ”[O]ur study provides novel evidence for the beneficial use of extremely low doses of THC, doses that do not elicit any psychoactive side effects, in order to protect the heart from ischemic insults. THC can be used as a pre-conditioning drug in cases in which ischemic insult to the heart is anticipated, such as during cardiac surgery or percutaneous coronary intervention.”
5. Cannabinoids Found to Reduce 90% of Skin Cancer in Just 20 Weeks

Researchers at the Tokyo Metropolitan Institute of Public Health had a study published this year in the Journal of Pharmacy and Pharmacology, which found that cannabinoids can reduce up to 90% of skin cancer in just a 20 week period in animal models.

Merry Christmas 2013 From KushArena!!

From my family to yours, I want to wish you all a very merry Christmas. Or if you don’t believe in Christmas, then merry ‘fill in the blank’! I hope your day is filled with family, friends, and good times. If you are smoking on that Santa Kush, make sure to puff, puff, pass. Don’t be a Grinch and hog the whole bowl to yourself!
christmas marijuana

What Is The Best Thing To Combine With Marijuana?

A few weeks ago I held a contest across my social networks asking the question “Nothing goes together better than marijuana and _______”. I was so overwhelmed by the amazing response (over 700 of you chimed in) that my team made the following infographic to display the results.
 Nothing Goes Together Better Than Marijuana and
Some basic takeaways from your response:
  • Amsterdam must be on to something because coffee was an outrageously common response. In fact, coffee was mentioned more than other individual response
  • Gateway drug? More drugs was a very common response, but ironically the lionshare of the responses did not mention harder drugs. Hash was most popular, followed by more marijuana, and then beer (which is by the way my least favorite alcohol in the world). It is also worth noting that if coffee was considered a drug more drugs would be the #1
  • 10 geniuses decided to state the obvious and answer “fire”
  • Love was included in 25 responses
  • My followers appear to be an enlightened bunch with responses like freedom, liberty, health and intellectualism greatly outranking responses like video games and even sex!
  • 20 of you responded Ed Rosenthal and/or my books. I appreciate you dearly
  • and 30 of you filled in the blank correct answer: Everything, because everything really is better when you’re high

Cannabis Can Successfully Treat Epilepsy In Children, Says New Study

 cannabidiol cbd cannabis marijuana
new study published in this month’s issue of the journal Epilepsy Behavior has found that many parents with epileptic children are turning to cannabis-based medicines to treat their seizures, and in a large majority of instances, it’s successful in doing so.
“Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek alternative treatments”, begins the study’s abstract. “This survey explored the use of cannabidiol-enriched cannabis in children with treatment-resistant epilepsy.”
For the study, researchers at the Department of Neurology at Stanford University examined 19 parents who have epileptic children, and who use cannabis-based medicines (such as tinctures and oils) to treat their child’s seizures. The average number of antiepileptic drugs tried before using cannabis was 12.
Researchers found that; “Sixteen (84%) of the 19 parents reported a reduction in their child’s seizure frequency while taking cannabidiol-enriched cannabis. Of these, two (11%) reported complete seizure freedom, eight (42%) reported a greater than 80% reduction in seizure frequency, and six (32%) reported a 25-60% seizure reduction.”
In addition, they found that; “Other beneficial effects included increased alertness, better mood, and improved sleep.” The only reported side effects were “drowsiness and fatigue”.
With this data, researchers conclude that “parents are using cannabidiol-enriched cannabis as a treatment for their children with treatment-resistant epilepsy”.
Recently the U.S. Federal Drug Administration gave approval to several studies intending to test the effectiveness of cannabis-based medicines on the treat of epilepsy in children.

Feds To Soon Release Memo Giving OK To Marijuana Banking

marijuana banking
Cannabis businesses wanting the ability to bank legitimately are likely to get at least a “yellow light” allowing them to do so as soon as the new year, says Jack Finlaw, Chief Legal Counsel for Colorado Governor John Hickenlooper.
“What we’re being told,” says Finlaw, “is probably in the first quarter of 2014 there will be some guidance issued that’s comparable to the Cole memo from theDepartment of Justice that will give, maybe not a green light, but a yellow light to banks to allow them to do business [with cannabis businesses] — to take deposits, to set up checking accounts, to set up small business loans, to allow these businesses to accept purchases through debit cards or credit cards, to allow what normal businesses are allowed to do.”
Just last week, the Bank Secrecy Advisory Group held a meeting in D.C. to begin talks about reforming banking regulations so that banks can legally do business with cannabis outlets.
Thursday’s news follows a DOJ announcement in August that it is “actively considering” how to regulate interactions between banks and cannabis retail outlets that are operating in states where they’re legal.
Given that numerous retail outlets are planning to begin selling recreational cannabis in Colorado on January 1st, we expect further news on this issue to come sooner, rather than later.

Marijuana Use Fairly Stable, Annual Survey Finds

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The annual Monitoring the Future survey of teen drug use is out, and anyone trying to use the numbers to argue that marijuana reform is causing a spike in teen pot-smoking is going to have a hard sell.
Here’s what MTF had to say about teen marijuana use:
“Annual marijuana prevalence peaked among 12th graders in 1979 at 51%, following a rise that began during the 1960s. Then use declined fairly steadily for 13 years, bottoming at 22% in 1992 — a decline of more than half. The 1990s, however, saw a resurgence of use. After a considerable increase (one that actually began among 8th graders a year earlier than among 10th and 12th graders), annual prevalence rates peaked in 1996 at 8th grade and in 1997 at 10th and 12th grades. After these peak years, use declined among all three grades through 2006, 2007, or 2008; after the declines, there began an upturn in use in all three grades, lasting for three years in the lower grades and longer in grade 12. In 2011 and 2012 there was some decline in use in grade 8, with 10th and 12th grades leveling in 2012. In 2010 a significant increase in daily use occurred in all three grades, followed by a nonsignificant increase in 2011. In 2012 there were non-significant declines for daily use in the lower grades and a leveling at 12th grade with use reaching 1.1%, 3.5%, and 6.5% in grades 8, 10, and 12, respectively.”
The bolding is ours. There are short term ups and downs, but they seem to be of mainly rhetorical and polemical significance.
If you look at the handy tables at the end of the report, you see that combined lifetime marijuana use for all three grades (8, 10, and 12), was at 30.7% last year, about the same as it was in 1995 (31.6%) or 2005 (30.8%). Much happens, but little changes.
Ditto for annual use: 26.1% in 1995, 23.4% in 2005, 24.7% last year.
Ditto for monthly use: 15.6% in 1995, 13.4% in 2005, 15.1% last year.
Ditto for daily use: 2.7% in 1995, 2.9% in 2005, 3.6% last year.
The daily use figures could be alarming (“Daily Teen Pot Smokers Up 25% Since 1995″), except the trend-line is not steadily upward, but varies from year to year (it was 3.7% in in 2001 and 2.7% in 2007).
Look for some terrifying spin about how the numbers show the kids are going to pot. But when you look at the numbers more closely and over time, when it comes to teens and marijuana, meh, what’s new?

Alaska Marijuana Legalization Campaign Has More Than Enough Signatures

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The ‘Campaign to Regulate Marijuana’ in Alaska looks like they have more than enough signatures to qualify a marijuana legalization initiative for the 2014 election. Alaska’s state election laws require 31,169 valid signatures to qualify an initiative for the ballot. The Alaska legalization campaign has 44,845 signatures according a media report out of Alaska.
There’s of course still the verification process, which can be as low as 50% sometimes. But the deadline for the final signature turn-ins is not until January 21, so there’s still time to submit even more signatures. With so much momentum in Alaska, I’d expect out of state money to start rolling in at an increasing rate. If they don’t have the required valid signatures on hand yet, they should be the end of the deadline.
As I’ve said many times before, I think Alaska, Oregon, Rhode Island, and Maine have stellar chances for legalizing marijuana during 2014. Other states sound like their campaigns are either waiting until 2016, or in the case of California, have a lot of different initiatives gathering signatures. I hope California can get behind one solid effort. Only time will tell.
To read the full initiative, go to this link here. A survey by Public Policy Polling found that 54 percent of Alaskans would support legalizing marijuana. The poll found the strongest support among voters ages 18 to 34, at 62 percent, and the lowest among voters 65 and older, at 43 percent. To donate to the campaign, go to this link here.

Fourth California Marijuana Legalization Initiative Filed

 vote for california marijuana initiatives
And then there were four. Famed marijuana cultivation expert Ed Rosenthal, the “Guru of Ganja,” announced Friday that he was filing The Cannabis Policy Reform Act of 2014 and dropped it in the mail to Sacramento the same day.
Three other initiatives have already been filed: The California Cannabis Hemp Initiative 2014, the perennial effort by followers of the late Jack Herer to legalize marijuana, which is in the signature gathering phase, but appears unlikely to make the ballot. The other two initiatives, The Control, Regulate and Tax Marijuana Act of 2014, filed by the Drug Policy Alliance, and The Marijuana Control, Legalization and Revenue Act of 2014 have both filed revised versions and are awaiting titles and ballot summaries from the state attorney general’s office.
Rosenthal’s Cannabis Policy Reform Act of 2014 would allow people 21 and over to possess up to three ounces of pot and grow up to 100 square feet outdoors (indoor limits would be energy-based and capped at 2600 watts.). The state would regulate commercial growing and sales, with licensing handled by the Department of Alcoholic Beverage Control.
There would be a 6% gross receipts tax at each stage of production, although farmers who sell direct to the public would be taxed only once. There would be no tax on high-CBD marijuana destined for the medical market.
The act would not create a per se limit for driver while impaired, nor would it allow localities to ban personal cultivation. Localities could ban stores, but only after such a measure is approved by voters.
“The deed is done: The Cannabis Policy Reform Act of 2014 is on its way to the State Capitol! Looking forward to true legalization, regulation, and taxation in California. Let’s help the police by freeing them from such trivial matters to better focus on the more serious problems of society, like violent crime,” Rosenthal wrote on his Facebook page.
Any putative 2014 California legalization initiative faces both high financial hurdles and a ticking clock. Initiatives need more than 500,000 signatures from registered voters to qualify for the ballot, an effort initiative watchers could cost a million dollars. And to get on the November ballot, signatures have to be in by April.
The Drug Policy Alliance says it will decide early next year whether to proceed with its initiative. Rosenthal said part of the reason he filed his initiative was that if the Drug Policy Alliance decides to move forward, it will at least have a good initiative (his) to work with.

How To Make The Perfect Marijuana Candy

 

Cannabis Candy Recipe

marijuana candy
There are a lot of people that think making cannabis candy is a difficult process, when in reality, it’s quite simple. As it usually is when making edibles, getting it right is tough. The candy not only has to be potent enough to be considered medicine but taste good as well! The candy is worthless if it doesn’t have both of those qualities. But making the perfect batch of cannabis candy treats is in the following recipe!
Ingredients:
Candy molds
Cooking spray
Metal spoon
2/3 cups white corn syrup
1 tsp flavoring of your choice (adjust if you want but this is really the perfect amount!)
Food coloring (so they look nice, obviously!)
Candy thermometer
1 cup water
2 cups sugar
9.5 grams of dry powdered hash
Directions:
First things first, spray the candy molds with cooking spray so that the mix doesn’t stick when you get to the step that requires it. Put the sugar and corn syrup together in a pot and put it on high heat until the mix begins to boil. Reduce the heat to low medium and keep an eye on the temperature. Once the temp hits 300, remove the heat and add in the hash and food coloring. Stir this mix vigorously. You need to make sure that the hash has been completely mixed in. About a minute should do it because the mix will start to harden soon after that. Add your candy mix in to the molds. You can either make them just candies or you can add in sticks to make them lollipops!
Let the mix harden in the mold and then remove and wrap them. This recipe will give you about 40 candies. You can always add in more hash but be sure that that’s the form of cannabis that you use. Kief could also be used in this recipe if you have enough of it. These candies last a good amount of time, about 2 to 3 hours on an empty stomach and an hour after a meal. No one should be afraid to make cannabis candy , especially when it’s such a benefit to those who are always on the go and enjoy eating their weed rather than smoking it. They’re very discreet but don’t let anyone sneak one behind your back!

The Top Ten Stupid Ways Stoners Got Busted In 2013

stupid idiots
Here at the National Cannabis Coalition, we believe marijuana will eventually be legalized nationwide.  Until then, cannabis consumers must remain vigilant to avoid the long arm of the law.  Nobody’s perfect and bad luck can help police take down even the most cautious tokers.  However, in 2013, a few stoners managed to do everything in their power to help police bust them for weed.  Here’s our look back at the top ten stupid ways stoners got busted in 2013, with the hope that readers will take these as important lessons in how to avoid a free ride in a cop car.

#10) Don’t park your car in the fire lane then complain to the cop with a joint behind your ear.

Blake James Roy of Texas parked his car in the fire lane at his apartment complex.  When he notices his car was towed, he took his small child with him to knock on the door of the apartment security guard.  When the guard, who also happened to be a Texas cop, noticed the joint Roy had behind his ear, Roy split, leaving his kid behind, only to be arrested seconds later when the cop ran him down.

#9) Don’t make weed deals by text message.

This October, Lt. Eric Danielson of the Andover Police bought a new cell phone with a new cell number.  At least, it was new to Danielson, but apparently an old pot customer of Nicholas DeLear Jr. in New Jersey, as Danielson got a text message on his new phone from DeLear offering a quarter pound of pot for sale.  Danielson sets up the deal at a local pizza parlor and DeLear shows up, but becomes suspicious.  Cops stop his car, the K-9 smells the weed, and Danielson matches his texts up with DeLear’s phone to make the bust.

#8) Don’t show cell phone pictures of your junk to strangers when you’re trafficking pounds of weed.

Jeffrey Ash of Fayetteville, Arkansas, was staying in an airport motel in Boise, Idaho, and meets a woman he’d like to impress.  Does he buy her flowers, ask her out for a drink, or engage conversation?  Nope, he whips out his cell phone and shows her a picture of his penis – because this works on women every time (just ask Brett Favre and Anthony Weiner).  The shocked woman calls the cops and when they’re interviewing Ash they discover he’s holding two duffel bags with 28.5 pounds of marijuana in them.

#7) Don’t lock your dog in the car with your jar of weed on a hot day.

Peter Giblin of Eastham, Massachusetts, left his golden retriever in his locked car in direct sunlight on bright spring day.  Someone reported the poor dog trapped in the hot car and police arrived to find the dog dehydrated and the car’s internal temperature at 106 degrees.  An hour later, Giblin returns to his car to receive not only the citation for animal cruelty, but also an arrest for the Mason jar full of weed packaged for resale that he’d left in the car with the dog.  Folks, don’t leave your dog in the car on a sunny day – even with the windows cracked open, a car interior on a 70-degree day can rise to over 100 degrees very quickly.

#6) Don’t invite cops into your weed-filled house to talk about a neighborhood car prowler.

Jonathan Moreno in South Hempstead, New York, was profiled by cops on burglary patrol.  They saw him peering into a parked 2005 Toyota at night.  Moreno helpfully explained that the car was his own and he could show them registration and title to prove it.  Why he invited them into his home to retrieve the documents when he had his digital scale, pot, and a pipe sitting out in plain view is a mystery.  A search later turned up six pounds of pot and almost $27,000.

#5) Don’t key somebody’s car and then invite cops into your weed-filled house to talk about it.

Tobias Bulger of Georgia let his anger for his father get the best of him and decided it would be a good idea to carve expletives into dad’s car’s paint job with a key.  When dad calls the cops, they decide to interrogate Bulger, who cheerfully led them right into his house, where the cops find a half ounce divided into separate baggies along with a digital scale.  Bulger is arrested and charged with possession with intent to distribute.

#4) Don’t speed and then when caught, tell cops all about your pot business.

Richard Seery of Pennsylvania was stopped for speeding around 3pm, doing 45mph in a 25mph zone.  The cop smelled pot and asked Seery about it and Seery gladly turned over a half ounce bag to the cop.  Soon, a drug dog is there helping to find the 17 pounds Seery had in luggage in the passenger compartment.  Next, the cops get a search warrant for his home and find a secret room with another 14 pounds of weed and about $50,000 in cash.  So, of course, he volunteers to help cops find his third stash of 36 pounds in a storage unit, his other stash of $200,000 in cash, and house he’d set up as a grow site.  And it all took place in East Hempfield Township.

#3) Don’t tailgate a sheriff’s car when you’re packing a pound of weed in your truck.

Kevin Bourque of Eureka, California, decided to tailgate a marked Humboldt County Sheriff’s car on Highway 101.  When the cop pulled into the slow lane, Bourque blazed on by him at 80mph in the 65mph zone.  After he’s pulled over, cops find a pound of weed and a sales ledger, and then get the warrant for his home where they find 497 plants and 29 pounds of bud.

#2) Don’t take your weed to court for your hearing on weed possession.

I could write an entire article on the people who went to the courthouse with weed.  Let’s just pick Jovon Graham of South Carolina, who went to court on a marijuana possession charge while holding.  After he was sentenced to half of his $813 fine or face 70 days in jail, the bailiff searches him, finds his weed, and Graham was promptly taken to jail on a second possession charge.

#1) Don’t meet your buddies to blaze up in the police parking lot.

Four young men from Totowa win the top award for Stupid 2013 when one of them goes to the state police to pick up paperwork for an impounded car.  While his three buddies are waiting for him, they decide to spark up right in the state troopers’ parking lot.  When a cop headed out for night patrol smelled the herb, he found and busted the three of them.  The guy who’d come to pick up his car from the state police was also holding and was busted as well.
Here’s to success in legalization in 2014 so more of these stories of stupidity don’t end with a conviction and a criminal drug record.

Cannabinoids May Help Revive Individuals After Cardiac Arrest

heart marijuana
An intriguing new study being published in next month’s issue of the journal Critical Care Medicine, and published online early by the National Institute of Health, has found that cannabinoid-based medicine administered through IV may provide a method of helping an individual resuscitate from cardiac arrest.
According to researchers, who examined rate models of cardiac arrest, “Blood temperatures decreased from 37°C to 33°C in 4 hours in animals in WIN55, 212-2 [cannabinoid receptor agonist] hypothermia group.. There was a significant improvement in myocardial function in the animals treated with WIN55, 212-2 hypothermia beginning at 1 hour after start of infusion.”
They continue; “WIN55, 212-2 hypothermia group was associated with significantly improved neurologic deficit scores and survival time when compared with placebo control group and WIN55, 212-2 with normal body temperature group.”
They conclude that; “In a rat model of cardiac arrest, better postresuscitation myocardial function, neurological deficit scores, and longer duration of survival were observed by the pharmacologically induced hypothermia with WIN55, 212-2. The improved outcomes of cardiopulmonary resuscitation following administration of WIN55, 212-2 appeared to be the results from its temperature reduction effects.”
The study, which can be found by clicking here, was conducted by researchers at the Weil Institute of Critical Care Medicine, and the Keck School of Medicine at the University of Southern California.

Know More About Cannabis!!


Cannabis (/ˈkænəbɪs/) is a genus of flowering plants that includes three putative varieties, Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These three taxa are indigenous to Central Asia, and South Asia. Cannabis has long been used for fibre (hemp), for seed and seed oils, for medicinal purposes, and as a recreational drug. Industrial hemp products are made from Cannabis plants selected to produce an abundance of fiber. To satisfy the UN Narcotics Convention, some Cannabis strains have been bred to produce minimal levels of THC, the principal psychoactive constituent responsible for the "high" associated with marijuana. Marijuana consists of the dried flowers of Cannabis plants selectively bred to produce high levels of THC and other psychoactive cannabinoids. Various extracts including hashish and hash oil are also produced from the plant.